英语新闻 英语考试 留学英语 TEM英语 CET英语 BEC英语 托福英语 雅思英语 英语作文 英语故事 英语笑话 娱乐英语 行业英语 英语学习 生活英语
工作英语 奥运英语 法律英语 英语口语 英文阅读 写作翻译 词汇语法 专四八级 四级六级 考研英语 职称英语 疯狂英语 英文简历 奥运知识 名人演说
您现在的位置: 3edu教育网 >> 英语角 >> 英语新闻 >> 生活Life >> 正文    3edu教育网,百万资源,完全免费,无需注册,天天更新!

Chinese scientists look for inhibitors for fat gene to help obese slim down

Chinese scientists look for inhibitors for fat gene to help obese slim down

分类:生活Life   更新:2010/4/14   来源:网络

Chinese scientists look for inhibitors for fat gene to help obese slim down

Chinese experts are looking for ways to block a human "fat" gene variant in order to treat obesity. But the treatment, if proved, may be years away.

"Recent studies have unequivocally associated the fat mass and obesity-associated (FTO) gene with the risk of obesity," said Chai Jijie, a research fellow with the Beijing-based National Institute of Biological Sciences, in a paper published Thursday in the latest issue of Nature.

"We are now focusing our study on identifying FTO-specific inhibitors," Chai told Xinhua Tuesday.

If successful, lead researcher Chai and his co-workers' study might finally help the obese slim down.

The FTO gene, sitting on human chromosome 16, packs on the pounds when it shows up in a variant form.

Scientists from across the world have confirmed since 2007 people of different cohorts carrying the FTO gene variants are more susceptible to obesity.

According to Chai, recent studies have suggested a higher risk of obesity caused by FTO variants in humans through increased food intake and reduced satiety.

A study in 2007 offered an easier way to grasp the connection between the gene variant and obesity.

The study, conducted by a group of British scientists, showed adults who carry two copies of the FTO gene variant weighed on average three kilograms more than those who don't.

Chai said about 12.6 percent of Chinese possessed both copies of the "fat" gene variants, in contrast with 45 percent of Europeans, quoting a study conducted by a group of Taiwan researchers in 2008.

But despite the lower frequency in Chinese people, he said "the effect of this FTO variant on body mass index is similar to what has been observed among Europeans."

In the paper, Chai and his colleagues described the crystal structure of the FTO protein, saying the structural study of the FTO gene might "serve as a foundation for the rational design of FTO inhibitors."

"If successful, we will test the effects of the inhibitors on animals," Chai said.

But he added that any therapy for obesity based on their studies could be years away.

"One thing is for sure - It will be a long way to go before obesity can be treated by targeting FTO, even if it turns out to be a valid target in the end," he said.

The prevalence of obesity has been increasing at an alarming speed in China over recent years.

A report posted on the Ministry of Science and Technology website said the country now has an obese population of more than 90 million, about 7 percent of the country's total population.

More than 200 million Chinese are overweight, the report said, adding that China's obese population will exceed 200 million within ten years.

Worldwide, about 2.3 billion adults are expected to be overweight by 2015 and more than 700 million obese, according to the World Health Organization.

Obesity raises the risk of diabetes, hypertension, cancer and premature death.

Source: Xinhua

| 设为首页 | 加入收藏 | 联系我们 | 版权申明 | 隐私策略 | 关于我们 | 手机3edu | 返回顶部 |