英语新闻 英语考试 留学英语 TEM英语 CET英语 BEC英语 托福英语 雅思英语 英语作文 英语故事 英语笑话 娱乐英语 行业英语 英语学习 生活英语
工作英语 奥运英语 法律英语 英语口语 英文阅读 写作翻译 词汇语法 专四八级 四级六级 考研英语 职称英语 疯狂英语 英文简历 奥运知识 名人演说
您现在的位置: 3edu教育网 >> 英语角 >> 英语新闻 >> 科技Science >> 正文    3edu教育网,百万资源,完全免费,无需注册,天天更新!

植物类药物化合物的可持续性生产

植物类药物化合物的可持续性生产

分类:科技Science   更新:2014/4/10   来源:网络

植物类药物化合物的可持续性生产

The biotechnological production of high-value plant-derived compounds using plant cell cultures is an attractive and sustainable alternative to extraction from whole plant material. However, the biosynthetic pathway leading to these compounds in plants is long and complex, with multiple enzymatic steps that are still largely uncharacterized at the genetic level. One of the main goals of the European Consortium SmartCell was to unravel the metabolic pathway leading to the periwinkle(小长春花) terpenoid indole alkaloids.
    植物类药物化合物的可持续性生产
    European scientists have made ground-breaking discoveries for improving the efficiency of the production of pharmaceuticals through plant biotechnology. Biotechnological production offers a cost-effective and environmentally friendly alternative to the chemical synthesis of rare and complex pharmaceutical compounds currently isolated from plants. The results have been achieved in the European SmartCell project coordinated by VTT Technical Research Centre of Finland. Several expensive anticancer alkaloid blockbusters used in chemotherapy, such as terpenoid indole alkaloids -- vinblastine and vincristine, are currently extracted from the plant Catharanthus roseus (Madagascar periwinkle) at high price. These compounds are used to treat Hodgkin's lymphoma(淋巴瘤), breast cancer, small-cell lung cancer and leukemia(白血病). Typically, very low levels accumulate in plant tissues, but chemical synthesis is not an economical alternative either due to their highly complex structures and specific stereochemical features. Internationally, much effort has been invested to develop more accessible and cost-effective sources of these drugs.
    The biotechnological production of high-value plant-derived compounds using plant cell cultures is an attractive and sustainable alternative to extraction from whole plant material. However, the biosynthetic pathway leading to these compounds in plants is long and complex, with multiple enzymatic steps that are still largely uncharacterized at the genetic level. One of the main goals of the European Consortium SmartCell was to unravel the metabolic pathway leading to the periwinkle(小长春花) terpenoid indole alkaloids.
    The SmartCell Consortium succeeded in elucidating the complete upstream segment of the terpenoid indole alkaloid biosynthesis pathway, as described in a ground-breaking article published in the journal Nature Communications.
    The complete pathway of twelve enzymes was reconstructed in tobacco plants, paving the way for cost-effective production of diverse therapeutic compounds. Moreover, cell culture technologies were developed, and the cultivation of the plant cells was scaled-up using bioreactors at VTT's pilot laboratory in Finland.
    "The use of plant cells as real green chemical factories is now becoming feasible for the first time. The technology developed and the experience gained on terpenoid indole alkaloids in this project can be utilized and applied to other compounds and plants as well," says the project coordinator Dr Kirsi-Marja Oksman-Caldentey from VTT.

| 设为首页 | 加入收藏 | 联系我们 | 版权申明 | 隐私策略 | 关于我们 | 手机3edu | 返回顶部 |